一、基本信息

靳祎，女，1977年7月，河北保定人，教授，博士，现任基础医学院副院长。河北省毒理学会第三届理事会常务理事。河北省生物化学与分子生物学学会教育专业分会副主任委员。荣获第四届全国高校教师教学创新大赛一等奖、“宝钢优秀教师奖”。近年来，一直从事纳米医学方向的研究，擅长基因药物递送体系构建及生物医学应用。针对骨关节炎和肿瘤治疗中的关键科学问题，系统探究其发病机制并开发新型诊疗策略，在癌症和骨关节炎的靶向治疗、免疫调控机制及氧化应激干预策略等方面取得重要进展。近五年主持省部‍级以上科研项目3项、教育厅重点项目1项。以第一作者或通讯作者发表SCI论文20余篇（其中中科院一区12篇）。获得河北省科技进步三等奖、二等奖各1项，保定市科技进步二等奖1项。

二、研究方向

纳米医学

三、科研项目

1. 中央引导地方科技发展资金项目，236Z1301G，基于调控炎症微环境的 DNAzyme 可注射水凝胶的构建及促进骨关节炎软骨修复的机制研究，2023/01-2025/12，15万元，在研，主持

2. 河北省自然科学基金面上项目，B2022201029，基于顺铂肾毒性保护的氧化循环加速器——黑磷/二氧化铈纳米酶的构建及作用机制，2022/01-2024/12，10万元，结题，主持

3. 河北省自然科学基金面上项目，B2018201157，基于Pgp靶点的DNAzyme靶向纳米载药体系的构建及其逆转肿瘤多药耐药的研究，2018/01-2020/12，6万元，结题，主持

4. 河北省教育厅重点项目，ZD2018036，基于 DNAzyme 的多功能纳米载药体系的构建及其在癌症基因联合热疗中的应用，2018/01-2020/12，5万元，结题，主持

5. 教育部重点实验室 “提升计划”项目，ts2020006，基于调控炎症微环境的BMP-2/DNAzyme水凝胶复合体系的构建及其促进骨愈合的研究，2020/01-2022/12，15万元，结题，主持

四、代表性论文

[1] Yi Jin, Zhenhua Li, Huifang Liu, Shizhu Chen, Feng Wang, Ling Wang, Nan Li, Kun Ge, Xinjian Yang*, Xing-Jie Liang*, Jinchao Zhang*. Biodegradable, multifunctional DNAzyme nanoflowers for enhanced cancer therapy. NPG Asia Mater, 2017, 9, e365.

[2] Yi Jin, Linna Liang, Xiaojing Sun, Guangshun Yu, Shizhu Chen, Shutang Shi, Huifang Liu, Zhenhua Li, Kun Ge, Dandan Liu, Xinjian Yang*, Jinchao Zhang*. Deoxyribozyme-nanosponges for improved photothermal therapy by overcoming thermoresistance. NPG Asia Mater, 2018, 10, 373-384.

[3] Huifang Liu#, Yi Jin#, Kun Ge, Guang Jia, Zhenhua Li, Xinjian Yang, Shizhu Chen, Min Ge, Wentong Sun, Dandan Liu*, Jinchao Zhang*. Europium-doped Gd2O3 nanotubes increase bone mineral density in vivo and promote mineralization in vitro. ACS Appl Mater Inter, 2017, 9(7): 5784-5792.

[4] Yi Jin, Xiaolong Liu, Huifang Liu, Shizhu Chen, Chunyue Gao, Kun Ge, Cuimiao Zhang, Jinchao Zhang*. Oxidative stress-induced apoptosis of osteoblastic MC3T3-E1 cells by hydroxyapatite nanoparticles through lysosomal and mitochondrial pathways. RSC Adv, 2017, 7:13010-13018.

[5] Yi Jin#, Shizhu Chen#, Nan Li, Yajing Liu, Gong Cheng, Cuimiao Zhang, Shuxiang Wang*, and Jinchao Zhang*. Defect-related luminescent bur-like hydroxyapatite microspheres induced apoptosis of MC3T3-E1 cells by lysosomal and mitochondrial pathways. Sci China Life Sci, 2018, 61(4): 464-475.

[6] Yi Jin, Shizhu Chen, Jianlei Duan, Guang Jia, Jinchao Zhang*. Europium-doped Gd2O3 nanotubes cause the necrosis of primary mouse bone marrow stromal cells through lysosome and mitochondrion damage. J Inorg Biochem, 2015, 146:28-36.

[7] 靳祎, 葛昆, 刘丹丹, 张金超, 刘会芳*, 梁兴杰*. 无机纳米材料在骨组织工程与再生医学中的应用. 科学通报, 2018, 63: 3808-3824.

[8] Chunyue Gao, Yi Jin*, Guang Jia, Xiaomin Suo, Huifang Liu, Dandan Liu, Xinjian Yang, Kun Ge, Xing-Jie Liang, Shuxiang Wang*, Jinchao Zhang*. Y2O3 nanoparticles caused bone tissue damage by breaking the intracellular phosphate balance in bone marrow stromal cells. ACS Nano, 2019, 13 (1), 313-323.

[9] Yi Jin#, Hao Wang#, Xiaona Li, Han Zhu, Danna Sun, Xiaojing Sun, Huifang Liu, Ziying Zhang, Lingzhi Cao, Changlin Gao, Hui Wang, Xing-Jie Liang, Jinchao Zhang*, Xinjian Yang*. Multifunctional DNA polymer-assisted upconversion therapeutic nanoplatform for enhanced photodynamic therapy. ACS Appl Mater Inter, 2020, 12 (24), 26832-26841.

[10] Wendi Huo#, Xiaona Li#, Bei Wang, Haoran Zhang, Jinchao Zhang, Xinjian Yang*, Yi Jin*. Recent advances of DNAzyme-based nanotherapeutic platform in cancer gene therapy. Biophys Rep, 2020, 6(6), 256–265.

[11] Fangfang Lv, Yan Jin, Xiaochen Feng, Miao Fan, Cui Ren, Xinyue Dai, Jinchao Zhang, Zhenhua Li, Yi Jin*, Huifang Liu*. Traceable metallic antigen release for enhanced cancer immunotherapy. J Nanopart Res, 2021, 23(6), 130.

[12] Hao Wang#, Yi Jin#, Yanli Tan, Han Zhu, Wendi Huo, Pei Niu, Zhenhua Li, Jinchao Zhang*, Xing-jie Liang, Xinjian Yang*. Photo-responsive hydrogel facilitates nutrition deprivation by an ambidextrous approach for preventing cancer recurrence and metastasis. Biomaterials, 2021, 275, 120992.

[13] Linna Liang#, Wendi Huo#, Bei Wang, Lingzhi Cao, Haoran Huo, Yixin Liu, Yi Jin*, Xinjian Yang*. DNAzyme-Based nanoflowers for reversing P-glycoprotein-mediated multidrug resistance in breast cancer. J Colloid Interf Sci, 2022, 608, 2985-2993.

[14] Wendi Huo, Xinjian Yang*, Bei Wang, Lingzhi Cao, Ziyuan Fang, Zhenhua Li, Huifang Liu, Xing-jie Liang, Jinchao Zhang*, Yi Jin*. Biomineralized hydrogel DC vaccine for cancer immunotherapy: A boosting strategy via improving immunogenicity and reversing immune-inhibitory microenvironment. Biomaterials, 2022, 288, 121722.

[15] Feng Wang, Yi Jin*, Xin Gao, Haoran Huo, Bei Wang, Biao Niu, Zihan Xia, Jinchao Zhang*, Xinjian Yang*. DNAzyme-assisted bioconstruction of logically activatable nanoplatforms for enhanced cancer therapy. J Colloid Interf Sci, 2022, 623, 1132-1141.

[16] Xin Gao#, Yixin Liu#, Wendi Huo#, Yuwei Song, Yu Chen, Jinchao Zhang, Xinjian Yang, Yi Jin*, Xing-Jie Liang*. RNA-cleaving DNAzymes for accurate biosensing and gene therapy. Nanoscale, 2023, 15(27), 11346-11365.

[17] Han Zhu#, Xin Gao#, Bei Wang, Biao Niu, Dandan Liu, Jinchao Zhang, Yi Jin*, Xinjian Yang*. A biodegradable hollow nanoagent enables a boosted chemodynamic therapy by simultaneous autophagy inhibition and macrophage reeducation. International Journal of Pharmaceutics, 2023, 643, 123248.

[18] Xin Gao, Bei Wang, Jingjing Li, Biao Niu, Lingzhi Cao, Xing-Jie Liang, Jinchao Zhang*, Yi Jin*, Xinjian Yang*. Catalytic Tunable Black Phosphorus/Ceria Nanozyme: A Versatile Oxidation Cycle Accelerator for Alleviating Cisplatin-Induced Acute Kidney Injury. Advanced Healthcare Materials, 2023, 12(30): e2301691.

[19] Lingzhi Cao, Xinjian Yang*, Yimei Li, Yang Yang, Qiulin Liu, Massimo Bottini, Yi Jin*, Bei Wang, Jinchao Zhang*, Xing-jie Liang*. Near-Infrared Light-Activatable DNA Tentacles for Efficient Inhibition of Tumor Metastasis by Bio-Orthogonal Cell Assembly. ACS Nano, 2024, 18, 18046−18057.

[20] Danna Sun#, Yuwei Song#, Wenyan Gao, Boyang Lin, Bei Wang, Xinjian Yang, Shaochun Li, Yi Jin*, Jinchao Zhang*. DNA-templated nanosheets for enhanced chemodynamic therapy and gene therapy to inhibit tumor recurrence and metastasis. International Journal of Pharmaceutics, 2024, 667, 124910.

[21] Xin Gao, Xinjian Yang*, Chunlin Deng, Yaxiao Chen, Yueying Bian, Xinyu Zhang, Yi Jin*, Jinchao Zhang*, Xing-Jie Liang*. A mitochondria-targeted nanozyme with enhanced antioxidant activity to prevent acute liver injury by remodeling mitochondria respiratory chain. Biomaterials, 2025, 18, 123133.

五、获奖情况

[1] 2013年保定市科学技术进步二等奖：箬叶多糖体内抑瘤及免疫调节作用的实验研究（20134239-1）

[2] 2017年河北省科学技术进步三等奖：骨质疏松症防治的基础与应用研究（2017JB3071-4）

[3] 2019年河北省科学技术进步二等奖：纳米稀土氧化物对骨代谢的调控及对骨质疏松防治的应用研究（2019JB2042-R7）

[4] 2022年河北省自然科学二等奖：人工合成无机纳米材料调控骨代谢的作用及机制（2022ZR2004-R3)