一、个人简介

李文娟，女，博士，毕业于首都医科大学；2009年至2014年在美国肯塔基大学和路易斯安那州立大学进行博士后训练。河北大学引进人才，现任职于基础医学院，受聘副教授，2016年获得药理学硕士导师资格；2022年受聘正教授。研究聚焦于肿瘤代谢重编程及其在肝癌治疗中的应用，特别是通过小分子天然植物提取物调控肿瘤细胞代谢途径，探索新型抗肿瘤策略。已在《Cancer Prevention Research》等本领域权威期刊以第一作者和通讯作者发表SCI论文30余篇，主持国家基金委青年基金项目一项，省自然科学基金面上项目三项，省人社厅基金一项，及校内基金。指导本科生申请并完成多项大学生创新创业项目，并承担本科生及留学生生物与分子生物学等7门本科专业课程的教学任务。

二、研究方向

1. 肿瘤代谢与化学预防

2. 线粒体功能与疾病的关系

3. 小分子天然植物提取物的生物活性

4. 肿瘤发生发展机制的研究

三、科研、教改项目

科研项目

1. 2023年河北省自然科学基金面上项目，项目编号：C2023201073，主持人，2023.1-2025.12

2. 2021河北大学医学学科培育项目，项目编号：2021A01（重点项目），主持人，2021.9-2024.8

3. 2019年河北省自然科学基金面上项目，项目编号：H2019201084，主持人，2019-2021

4. 2016国家青年基金，项目批准号：81502477，主持人，2016-2018

5. 2016河北省留学人员科技活动项目择优资助项目，项目编号：C2015003021，主持人，2016-2018

6. 2015年河北省自然科学基金资助面上项目，项目编号：H2015201119，主持人，2015-2017

7. 2015学科建设项目，项目编号：2015A1001，主持人，2015-2017

8. 2015河北大学引进人才项目，项目编号：2015-307，主持人，2015-2018。

教改项目

1. 2020年河北大学题（卷）库项目，2020年，申请人。

2. 2020年度河北大学“新医科”教学改革研究项目，项目编号：2020XYKB-13，线上线下双语教学在临床医学专业学生培养中的研究与实践，主持人

3. 2020年河北大学第三批精品实验项目，项目编号：2021-BZ-JPSY49，2021-2022，小鼠肝脏组织总蛋白提取及含量测定，主持人。

4. 2021年河北省教师教育教学信息化交流活动，高等教育组一等奖。

四、代表性论文

1. Xiangyang Zhou, Di Wu, Tian Mi, Ruohan Li, Tao Guo, Wenjuan Li#. Icaritin activates p53 and inhibits aerobic glycolysis in liver cancer cells. Chem Biol Interact. 2024 Mar 1;392:110926.

2. Xiangyang Zhou, Di Wu, Linmiao Zhu, Ruohan Li, Haitao Yu and Wenjuan Li#. Withaferin A Inhibits Liver Cancer Tumorigenesis by Suppressing Aerobic Glycolysis through the p53/IDH1/HIF-1α Signaling Axis. Current Cancer Drug Targets. 2024:24(5), 534-545.

3. Kaiyue Zhang, Di Wu, Limin Chang, Wenhao Duan, Yong Wang, Wenjuan Li#, Jianglei Qin#. Cellulose based self-healing hydrogel through Boronic Ester connections forwound healing and antitumor applications. International Journal of Biological Macromolecules. 2023:230, 123294.

4. Yuehua Qi, Chunjing Zhang, Di Wu, Yue Zhang, Yunfeng Zhao, Wenjuan Li#. Indole-3-Carbinol Stabilizes p53 to Induce miR-34a, Which Targets LDHA to Block Aerobic Glycolysis in Liver Cancer Cells. Pharmaceuticals. 2022: 15, 1257.

5. 周向阳,李仲凯,郝腾飞,丁光硕,郑文慧,李文娟#，重组人瘦素蛋白的原核表达、纯化和生物学活性鉴定，河北大学学报(自然科学版)，2022：42，5，524-531.

6. Danyang Chen, Xiaojun Liu, Yuehua Qi, Xiangbo Ma, Yong Wang, Hongzan Song, Youliang Zhao, Wenjuan Li#, Jianglei Qin#. Poly(aspartic acid) based self-healing hydrogel with blood coagulation characteristic for rapid hemostasis and wound healing applications. Colloids and Surfaces B: Biointerfaces. 2022: 214, 112430.

7. Danyang Chen, Xiangyang Zhou, Liming Chang, Yong Wang, Wenjuan Li#, Jianglei Qin#. Hemostatic Self-Healing Hydrogel with Excellent Biocompatibility Composed of Polyphosphate-Conjugated Functional PNIPAM-Bearing Acylhydrazide. Biomacromolecules. 2021: 22,2272-2283.

8. Jiafu Shen, Limin Chang, Danyang Chen, Yong Wang, Wenjuan Li#, Yingna He#, Jianglei Qin#. Cross-linking induced thermo-responsive self-healable hydrogels with gel‑sol–gel transition constructed on dynamic covalent bond. Journal of Polymer Research. 2021: 28,132.

9. Kaiyue Xu, Chunjing Zhang, Youbo Li, Xin Xi, Lishuang Zheng, Ming Meng, Tongtong Liu, Yunfeng Zhao#, Wenjuan Li#. Withaferin A suppresses skin tumor promotion by inhibiting proteasome-dependent isocitrate dehydrogenase 1 degradation. Translational Cancer Research, 2019: 8,2449-2460.

10. Xuemeng Wang, Limin Chang, Xiaojie Lang, Heng An, Yong Wang, Wenjuan Li#, Jianglei Qin#. Cross-linking induced thermo-responsive self-healable hydrogels with temperature regulated light emission property. Journal of Polymer Research. May 2019: 26,115.

11. Liye Cao*, Wen-Juan Li*, et al. Inflammatory cytokine-induced expression of MASTL is involved in hepatocarcinogenesis by regulating cell cycle progression. Oncology Letters. 2019: 17, 3163-3172.

12. Xuemeng Wang, Kaiyue Xu, Haicui Yao, Limin Chang, Yong Wang, Wenjuan Li#, Youliang Zhao, Jianglei Qin#. Temperature-Regulated Aggregation-Induced Emissive Self-Healable Hydrogel for Controlled Drug Delivery. Polymer Chemistry. 2018: 9:5002-5013.

13. Heng An, Kaiyue Xu, Limin Chang, Yong Wang, Jianglei Qin#, Wenjuan Li#. Thermo-responsive self-healable hydrogels with extremely mild base degradability and bio-compatibility. Polymer. 2018: 147:38-47.

14. 许凯悦，张春晶，李文娟。IDH1在肿瘤发生发展中的作用及其调控机制的研究进展。中国肿瘤生物治疗杂志。2018: 25（6）：573-579.

15. Wenjuan li, Chunjing Zhang, H Du, et al. Withaferin A suppresses the up-regulation of acetyl-coA carboxylase 1 and skin tumor formation in a skin carcinogenesis mouse model. Mol Carcinog. 2016 Nov;55(11):1739-1746.

16. Wenjuan Li, Chunjing Zhang, Amy Ren, et al. Shikonin Suppresses Skin Carcinogenesis via Inhibiting Cell Proliferation. PLOS ONE, 10(5), e0126459, May 11 2015.

17. Wenjuan Li, Chunjing Zhang, Jackson K, et al. UCP2 knockout suppresses mouse skin carcinogenesis. Cancer Prev Res, 8(6), 487-491,JUN 2015.

18. Wenjuan Li, Chunjing Zhang, Runhua Shi, et al. Mitochondrial uncoupling protein 2 promotes skin carcinogenesis. CANCER RESEARCH, 439(74),OCT 1 2014. (Meeting Abstract)

19. Wenjuan Li, Joan Liu and Yunfeng Zhao. PKM2 inhibitor shikonin suppresses TPA-induced mitochondrial malfunction and proliferation of skin epidermal JB6 cells. Molecular Carcinogenesis, 53(5),403-412, MAY 2014.

20. Wenjuan Li, Joan Liu, Kasey Jackson, et al. Sensitizing the Therapeutic Efficacy of Taxol with Shikonin in Human Breast Cancer Cells. PLOS ONE, 9(4), e94079, APR 7 2014.

21. Wenjuan Li, Krystle Nichols, Cherie-Ann Nathan, et al. Mitochondrial uncoupling protein 2 is up-regulated in human head and neck, skin, pancreatic, and prostate tumors. Cancer Biomarkers 13(5), 377-383, 24 Dec 2013.

22. Wenjuan Li and Yunfeng Zhao. Withaferin A suppresses tumor promoter 12-O-tetradecanoylphorbol 13-acetate-induced decreases in isocitrate dehydrogenase 1 activity and mitochondrial function in skin epidermal JB6 cells. Cancer Sci, 104(2), 143-148, FEB 2013.

23. Wenjuan Li and Yunfeng Zhao. “Warburg Effect” and Mitochondrial Metabolism in Skin Cancer. J Carcinogene Mutagene, S4, 002,2012.

24. Delira Robbins, Wenjuan Li, Katie Humphrey and Yunfeng Zhao. Redox factor-1 mediates inflammatory response during tumor promotion in skin epidermal JB6 cells. Scientific Research, 1(3), 19-24,2012.

25. Xiaoling Guo*, Wenjuan Li*, Qing Wang, et al. AKT Activation by Pdcd4 Knockdown Up-Regulates Cyclin D1 Expression and Promotes Cell Proliferation. Genes & Cancer, 2011; 2: 818-828. (*These authors contributed equally to this work.)

26. Haijun Zhang, Wenjuan Li, Michael J. Franklin, et al. Dudek. Polymorphisms in DNA Repair Gene XRCC1 and Skin Cancer Risk: A Meta-analysis. ANTICANCER RESEARCH, 2011; 31: 3945-3952.

27. Hai-Jun Zhang, Wen-Juan Li, Yan-Yan Gu, et al. p14ARF interacts with E2F factors to form p14ARF-E2F/partner-DNA complexes repressing E2F-dependent transcription. J Cell Biochem, 2010; 109: 693-701.

28. Wen-Juan Li, et al. Induction of p14ARF by E2F1 contributes partially to 8-chloro-adenosine induced apoptosis in human lung cancer H1299 cells. Chemotherapy, 2009; 55; 335-343.

29. Hai-Jun Zhang, Wen-Juan Li, Sheng-Yong Yang, et al. 8-Chloro-adenosine-induced E2F1 promotes p14ARF gene activation in H1299 cells through displacing Sp1 from multiple overlapping E2F1/Sp1 sites. J Cell Biochem, 2009; 106: 464-472.

30. LIU Chang, LI Wen-Juan, CHEN Yu, et al. 8-Chloro-adenosineinduced H3K79me2 Promotes Transcriptional Activation of NBS1 and p21 Genes in Response to DNA. Chin J of Biochemistry and Molecular Biol, 2009, 25: 0-976.

31. LI Wen-juan, CHEN Wei, FU Xiao-bing, et al. Expression of matrix metalloproteinases and their inhibitors in fetal skin and their biological significance. Chin Crit Care Med, 2006; 18: 303-306.

32. LI Wen-juan, CHEN Wei, ZHU Ren-zhi, et al. Fusion expression and purity of human leptin in E. coli. Chin J Exp Surg, 2006; 23: 336-338.

33. LI Wen-juan, CHEN Wei, FU Xiao-bing, et al. The signal transduction pathway induced by human leptin. Med J Chin PLA, 2006; 31: 172-174.

34. LI Wen-juan, CHEN Wei, WANG Haibing, et al. Gene expression of matrix metalloproteinases and their inhibitor-2 in proliferative and mature hypertrophic scars. Infection. Inflammation. Repair, 2006; 1: 16-19.

35. Wei Chen, Xiao-Bing Fu, Shi-Li Ge, et al. Exogenous acid fibroblast growth factor inhibits ischemia-reperfusion-induced damage in intestinal epithelium via regulating P53 and P21WAF-1 expression. World J Gastroenterol, 2005; 11: 6981-6987.

36. Wei Chen, Xiao-Bing Fu, Shi-Li Ge, et al. Acid fibroblast growth factor reduces rat intestinal mucosal damage caused by ischemia-reperfusion insult. World J Gastroenterol, 2005; 11: 6477-6482.

37. Li Wen-juan, Chen Wei, Fu Xiaobing, et al. Characteritics of expression of matrix metalloproteinase and its inhibitor in hypertrophic scars and their biological significance. Infection. Inflammation. Repair, 2005; 4: 2+17-19.

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