一、基本信息
张元功,理学博士,副教授,博士研究生导师。Email:zhangyuangong@hbu.edu.cn。主持和参加国家自然科学基金项目5项,河北省自然科学基金2项、省教育厅青年拔尖项目1项,迄今已在国内外学术期刊发表研究论文多篇。
二、研究方向
主要研究方向为生物医用高分子材料。主要为药物控制释放载体的大分子设计与合成,功能性高分子材料的设计、合成及应用等。
三、主要科研/教改项目
1. 国家自然科学基金(面上,82471463),2025.01-2028.12,主持。
2. 精准医学创新发展联合基金培育项目(H2025201041),2025.01-2027.12,主持。
3. 中央引导地方科技发展资金项目(自由探索类基础研究,226Z2604G),完成。
4. 国家自然科学基金(青年,22007026),完成。
5. 河北省高等学校科学技术研究项目(BJ2021009),完成。
6. 河北省自然科学基金(青年,B2020201027),完成。
四、代表性论文
1. Targeting MCR-3 and membrane biosynthesis: mechanistic insights into pterostilbene-colistin synergy. Microbiology Spectrum, 2026, 14: e02588-25
2. pH-Responsive Glycopolymers as Fluorine-19 Magnetic Resonance Imaging Agents Crossing the Blood–Brain Barrier. ACS Applied Polymer Materials, 2025, 7: 6674-6681.
3. An Aggregation-Induced Emission Fluorescent Probe for Detecting β-Amyloid Plaques. Chemistryselect, 2025, 10, e03358.
4. Fluorometric/19F MRI probes for imaging of amyloid-β fibrils. Chemistry Letters, 2025, 54(4): upaf071.
5. Dissimilar effects of the hydrophilic carbon dots on the amyloid aggregation of two model proteins and the mechanism discussion. Journal of Molecular Recognition, 2024, 37: e3085.
6. Air-stable and reusable porous silica-supported ultrafine Nix-NiO nanoparticles for semihydrogenation of alkynes, Applied Surface Science, 2024, 654: 159411.
7. Effect of mono- and diketone group in curcumin analogues on amyloid fibrillation of hen egg white lysozyme, Biophysical Chemistry, 2023, 292: 106913.
8. Development of a cellulose-based hydrogel with glucose-lowering, ROS-scavenging, and colorimetric detection properties, Cellulose, 2023, 30: 10285-10296.
9. Study of the temperature/HCO3- response mechanism of hyperbranched poly(bis-acrylamide)s. Polymer Journal, 2023, 55,1295-1305.
10. One-Pot Free Radical Polymerization/Hydroxyl-Isocyanate Reaction: A Facile Strategy to Synthesize Hyperbranched Glycopoly(MaM/IM) with Tunable Structures. Macromolecules, 2021, 54, 2068-2078.